Quinethazone

Modify Date: 2024-01-11 18:31:53

Quinethazone structure	Common Name	Quinethazone
	CAS Number	73-49-4	Molecular Weight	289.739
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₂ClN₃O₃S	Melting Point	250 - 252ºC
	MSDS	N/A	Flash Point	N/A

Use of Quinethazone

Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research[1][2].

Name	7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
Synonym	More Synonyms

Description	Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
In Vivo	Quinethazone (50 mg/kg; p.o.; daily for 2 weeks) lowers blood pressure of renal hypertensive rats in association with a decrease in potassium but no change in water or sodium contents of aorta wall[1]. Animal Model: Five- to 6-week-old Long Evans male rats, hypertension model[1] Dosage: 50 mg/kg Administration: Oral, daily for 2 weeks Result: Had no significant effect on sodium or water distribution in arterial tissue of hypertensive rats, but decreased approximate 20% intra-cellular content of potassium
References	[1]. FREED SC. MECHANISM OF ANTI-HYPERTENSIVE ACTION OF QUINETHAZONE. Proc Soc Exp Biol Med. 1963 Nov;114:421-2. [2]. Angelopoulos B, et al. Experimental investigation and observations on the diuretic action of quinethazone. Med Pharmacol Exp Int J Exp Med. 1966;14(6):528-36.

Density	1.4±0.1 g/cm3
Melting Point	250 - 252ºC
Molecular Formula	C₁₀H₁₂ClN₃O₃S
Molecular Weight	289.739
Exact Mass	289.028778
PSA	109.67000
LogP	0.49
Index of Refraction	1.582

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA1679500

CHEMICAL NAME :: 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-7-chloro-2-ethyl-4-oxo-

CAS REGISTRY NUMBER :: 73-49-4

BEILSTEIN REFERENCE NO. :: 0818554

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-Cl-N3-O3-S

MOLECULAR WEIGHT :: 289.76

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,201,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5486 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

RIDADR	NONH for all modes of transport

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quinethazone

7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydro-quinazoline-6-sulfonic acid amide

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Aquamox

7-Chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydro-6-quinazolinesulfonamide

7-Chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

Idrokin

DC Chemicals Limited
China
Product Name: Quinethazone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: quinethazone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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