CE-245677

Modify Date: 2024-01-10 10:52:50

CE-245677 structure	Common Name	CE-245677
	CAS Number	717899-97-3	Molecular Weight	513.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₂Cl₂N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CE-245677

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

Name	CE-245677

Description	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Research Areas >> Cancer Research Areas >> Cardiovascular Disease
In Vitro	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].
In Vivo	CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1].
References	[1]. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.

Molecular Formula	C₂₄H₂₂Cl₂N₆O₃
Molecular Weight	513.38

DC Chemicals Limited
China
Product Name: CE-245677
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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