CE-245677
Modify Date: 2024-01-10 10:52:50
CE-245677 structure
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Common Name | CE-245677 | ||
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| CAS Number | 717899-97-3 | Molecular Weight | 513.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H22Cl2N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CE-245677CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
| Name | CE-245677 |
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| Description | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
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| Related Catalog | |
| In Vitro | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1]. |
| In Vivo | CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1]. |
| References |
| Molecular Formula | C24H22Cl2N6O3 |
|---|---|
| Molecular Weight | 513.38 |