Aligeron

Modify Date: 2024-01-09 07:04:53

Aligeron structure	Common Name	Aligeron
	CAS Number	70713-45-0	Molecular Weight	292.41800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₄N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Aligeron

Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.

Name	1-benzhydryl-4-prop-2-enylpiperazine
Synonym	More Synonyms

Description	Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Cardiovascular Disease
In Vitro	Aligeron shows a broad spectrum of antagonistic action against different spasmogens in different isolated organs. The experiments on isolated perfused rabbit artery shows the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline[1]. The effect of aligeron in vitro lacks selectivity and is probably due to interference with the action of Ca2+[3].
In Vivo	In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression[2].
References	[1]. Miyares K, et al. Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli. Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):473-6. [2]. Dimov S, et al. Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats. Methods Find Exp Clin Pharmacol. 1983;5(2):89-95. [3]. Nikolov R, et al. Study on the prostaglandin antagonistic activity of aligeron and piracetam. Methods Find Exp Clin Pharmacol. 1982 Aug-Sep;4(6):387-95.

Molecular Formula	C₂₀H₂₄N₂
Molecular Weight	292.41800
Exact Mass	292.19400
PSA	6.48000
LogP	3.45540
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6655000

CHEMICAL NAME :: Piperazine, 1-(diphenylmethyl)-4-(2-propenyl)-

CAS REGISTRY NUMBER :: 70713-45-0

BEILSTEIN REFERENCE NO. :: 0543456

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H24-N2

MOLECULAR WEIGHT :: 292.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 202 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 38500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987

1-benzhydryl-4-allyl-piperazine

1-(Diphenylmethyl)-4-(2-propenyl)piperazine,dihydrochloride

1-(Diphenylmethyl)-4-(2-propenyl)piperazine

Aligeron

1-allyl-4-benzhydryl-piperazine

Piperazine,1-(diphenylmethyl)-4-(2-propenyl)

1-(diphenylmethyl)-4-(prop-2-en-1-yl)piperazine

DC Chemicals Limited
China
Product Name: Aligeron
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

Aligeron suppliers

Price: $120/1mg

Reference only. check more Aligeron price

Aligeron

Use of Aligeron

Names

Aligeron Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms