TCN 237 dihydrochloride
Modify Date: 2025-08-26 23:54:21
TCN 237 dihydrochloride structure
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Common Name | TCN 237 dihydrochloride | ||
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| CAS Number | 700878-19-9 | Molecular Weight | 375.86800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H23ClFN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TCN 237 dihydrochlorideNMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.Preparation of 2-[(4-benzyl)-1-piperidinyl)methyl]benzimidazole-5-ols as NMDA NR2B receptor antagonists for the treatment of neuropathic pain.By McCauley, James A.; Claremon, David A.; Liverton, Nigel J. From PCT Int. Appl. (2004), WO 2004048364 A1 20040610. NR2B-Selective N-Methyl-D-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted BenzimidazolesBy McCauley, John A.; Theberge, Cory R.; Romano, Joseph J.; Billings, Susan B.; Anderson, Kenneth D.; Claremon, David A.; Freidinger, Roger M.; Bednar, Rodney A.; Mosser, Scott D.; Gaul, Stanley L.; et alFrom Journal of Medicinal Chemistry (2004), 47(8), 2089-2096. |
| Name | 2-((4-(2-fluorobenzyl)piperidin-1-yl)methyl)-1H-benzo[d]imidazol-5-ol hydrochloride |
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| Synonym | More Synonyms |
| Description | NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.Preparation of 2-[(4-benzyl)-1-piperidinyl)methyl]benzimidazole-5-ols as NMDA NR2B receptor antagonists for the treatment of neuropathic pain.By McCauley, James A.; Claremon, David A.; Liverton, Nigel J. From PCT Int. Appl. (2004), WO 2004048364 A1 20040610. NR2B-Selective N-Methyl-D-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted BenzimidazolesBy McCauley, John A.; Theberge, Cory R.; Romano, Joseph J.; Billings, Susan B.; Anderson, Kenneth D.; Claremon, David A.; Freidinger, Roger M.; Bednar, Rodney A.; Mosser, Scott D.; Gaul, Stanley L.; et alFrom Journal of Medicinal Chemistry (2004), 47(8), 2089-2096. |
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| Related Catalog | |
| References |
| Molecular Formula | C20H23ClFN3O |
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| Molecular Weight | 375.86800 |
| Exact Mass | 375.15100 |
| PSA | 52.15000 |
| LogP | 4.60220 |
| InChIKey | JYUWGWCFJMDMND-UHFFFAOYSA-N |
| SMILES | Cl.Cl.Oc1ccc2nc(CN3CCC(Cc4ccccc4F)CC3)[nH]c2c1 |
| Storage condition | 2-8℃ |
| TCN 237 dihydrochloride |
| NMDA-IN-1 |