Pelubiprofen

Modify Date: 2024-01-09 19:46:46

Pelubiprofen Structure
Pelubiprofen structure
Common Name Pelubiprofen
CAS Number 69956-77-0 Molecular Weight 258.312
Density 1.2±0.1 g/cm3 Boiling Point 457.4±34.0 °C at 760 mmHg
Molecular Formula C16H18O3 Melting Point N/A
MSDS N/A Flash Point 244.5±22.2 °C

 Use of Pelubiprofen


Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

 Names

Name 2-[4-[(E)-(2-oxocyclohexylidene)methyl]phenyl]propanoic acid
Synonym More Synonyms

 Pelubiprofen Biological Activity

Description Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].
Related Catalog
Target

COX-2

References

[1]. Choi IA, Baek HJ, et al. Comparison of the efficacy and safety profiles of a pelubiprofen versus celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, phase III, non-inferiority clinical trial. BMC Musculoskelet Disord. 2014 Nov 18;15:375.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 457.4±34.0 °C at 760 mmHg
Molecular Formula C16H18O3
Molecular Weight 258.312
Flash Point 244.5±22.2 °C
Exact Mass 258.125580
PSA 54.37000
LogP 2.76
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.605

 Synonyms

2-[4-(2-oxo-1-cyclohexyliden methyl)-phenyl]propionic acid
Benzeneacetic acid, α-methyl-4-[(E)-(2-oxocyclohexylidene)methyl]-
2-Ocmpp
2-{4-[(E)-(2-Oxocyclohexylidene)methyl]phenyl}propanoic acid
(+/-)-2-[4-(2-Oxocyclohexylidenemethyl)phenyl]propionic acid
(±)-p-[[(E)-2-Oxocyclohexylidene]methyl]hydratropic Acid
Pelubiprofen
Pelubiprofen (JAN/INN)
2-[4-(2-oxo-1-cyclohexylidenemethyl)phenyl]propionic acid
MFCD00870907
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