Dibenzo[f,h]pyrrolo[1,2-b]isoquinoline,9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-, (13aR)-

MOLECULAR FORMULA :

C24-H27-N-O4

MOLECULAR WEIGHT :

393.52

WISWESSER LINE NOTATION :

T D5 B6 K666 DNJ MO1 NO1 RO1 SO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

65 mg/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :

NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

32 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

REFERENCE :

NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

REFERENCE :

NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

42 mg/kg

TOXIC EFFECTS :

Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :

NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

12 mg/kg/24D-I

TOXIC EFFECTS :

Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - ulceration or bleeding from large intestine Blood - other changes

REFERENCE :

NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

24 mg/kg/24D-I

TOXIC EFFECTS :

Liver - other changes Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :

NCICP* Progress Report Submitted to the National Cancer Institute by Charles Pfizer & Co. Volume(issue)/page/year: -,77,1964