ML00253764
Modify Date: 2025-08-25 17:24:16
ML00253764 structure
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Common Name | ML00253764 | ||
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| CAS Number | 681847-92-7 | Molecular Weight | 413.712 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19BrClFN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML00253764ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1]. |
| Name | 2-{2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazole hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1]. |
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| Related Catalog | |
| In Vitro | ML00253764(0.001-50 μM, 24 h or 72 h)对人胶质母细胞瘤细胞增殖具有显著的时间和浓度依赖性抑制活性，其中作用于 U-118 细胞的 IC50 值为 6.56 μM，可以诱导U-87细胞凋亡，且在这两种细胞系中均表现出显著的 ERK1/2 磷酸化抑制作用[1]。 |
| In Vivo | ML00253764(30 mg/kg, s.c., daily, 34 days) 可抑制感染 U-87 细胞的 CD nu/nu 雄性小鼠肿瘤生长[1]。 |
| References |
| Molecular Formula | C18H19BrClFN2O |
|---|---|
| Molecular Weight | 413.712 |
| Exact Mass | 412.035309 |
| InChIKey | WCPPZGPJRHLSKP-UHFFFAOYSA-N |
| SMILES | COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 |
| 1H-Imidazole, 2-[2-[2-(5-bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-, hydrochloride (1:1) |
| 2-{2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl}-4,5-dihydro-1H-imidazole hydrochloride (1:1) |
| MFCD28133377 |