CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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NK6825000
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CHEMICAL NAME :
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1,3-Indandione, 2-(p-(trifluoromethyl)phenyl)-
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CAS REGISTRY NUMBER :
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6723-40-6
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C16-H9-F3-O2
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MOLECULAR WEIGHT :
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290.25
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WISWESSER LINE NOTATION :
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L56 BV DV CHJ CR DXFFF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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198 mg/kg
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TOXIC EFFECTS :
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Blood - hemorrhage Liver - fatty liver degeneration Sense Organs and Special Senses (Eye) - visual field changes
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REFERENCE :
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APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,425,1970
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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125 mg/kg
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TOXIC EFFECTS :
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Blood - hemorrhage Liver - fatty liver degeneration Sense Organs and Special Senses (Eye) - visual field changes
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REFERENCE :
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APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,425,1970
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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>2810 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Gastrointestinal - nausea or vomiting
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REFERENCE :
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APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,425,1970
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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123 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Gastrointestinal - nausea or vomiting Behavioral - somnolence (general depressed activity)
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REFERENCE :
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APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,425,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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756 mg/kg/28D-I
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TOXIC EFFECTS :
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Blood - normocytic anemia Blood - pigmented or nucleated red blood cells Related to Chronic Data - death
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REFERENCE :
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APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 28,425,1970
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