Trehalose 6-behenate
Trehalose 6-behenate structure
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Common Name | Trehalose 6-behenate | ||
|---|---|---|---|---|
| CAS Number | 66755-19-9 | Molecular Weight | 664.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H64O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Trehalose 6-behenateTrehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant. |
| Name | Trehalose 6-behenate |
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| Description | Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant. |
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| Related Catalog | |
| Target |
Trehalose 6-behenate (TDB) exerts its effect through binding to the macrophage-inducible C-type lectin Mincle, a pathogen recognition receptor (PRR) that recognises pathogen-associated molecular patterns (PAMPs). The potential of Th1/Th17 skewing adjuvants in vaccine development provides a very real incentive for better definition of the structural motifs required for Mincle binding. Mincle is highly conserved between mice and humans, with 85 % protein similarity. In addition to being a receptor for TDMs, Trehalose 6-behenate (TDB), and the spliceosome-associated protein (SAP)130 (which activates Mincle at a binding site different to that involved in carbohydrate recognition), Mincle is also a receptor for Candida albicans, Malassezia, and Fonsecaea pedrosoi[1]. |
| References |
| Molecular Formula | C34H64O12 |
|---|---|
| Molecular Weight | 664.86 |