Gomisin J

Modify Date: 2025-08-21 09:44:16

Gomisin J structure	Common Name	Gomisin J
	CAS Number	66280-25-9	Molecular Weight	388.454
	Density	1.161	Boiling Point	587.5±50.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₈O₆	Melting Point	148-149 ºC
	MSDS	N/A	Flash Point	309.1±30.1 °C

Use of Gomisin J

Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2].

Name	Gomisin J
Synonym	More Synonyms

Description	Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity[1]. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cardiovascular Disease Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Metabolic Disease
Target	AMPK Ca2+
References	[1]. Ye BH, et al. Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertens Res. 2015 Mar;38(3):169-77. [2]. Kim M, et al. Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells. J Agric Food Chem. 2015 Nov 11;63(44):9729-39.

Density	1.161
Boiling Point	587.5±50.0 °C at 760 mmHg
Melting Point	148-149 ºC
Molecular Formula	C₂₂H₂₈O₆
Molecular Weight	388.454
Flash Point	309.1±30.1 °C
Exact Mass	388.188599
PSA	77.38000
LogP	4.80
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.556
InChIKey	PICOUNAPKDEPCA-TXEJJXNPSA-N
SMILES	COc1c(O)cc2c(c1OC)-c1c(cc(O)c(OC)c1OC)CC(C)C(C)C2

Hazard Codes	Xi

(3aS,R-Biar)-3a...

CAS#:110397-81-4

Gomisin J

CAS#:66280-25-9

Literature: Tanaka, Masahide; Ohshima, Toshihiro; Mitsuhashi, Hiroshi; Maruno, Masao; Wakamatsu, Takeshi Tetrahedron, 1995 , vol. 51, # 43 p. 11693 - 11702

Schizandrin A

CAS#:61281-38-7

Gomisin J

CAS#:66280-25-9

Literature: Tanaka, Masahide; Ohshima, Toshihiro; Mitsuhashi, Hiroshi; Maruno, Masao; Wakamatsu, Takeshi Tetrahedron, 1995 , vol. 51, # 43 p. 11693 - 11702

Precursor 2
CAS#:110397-81-4 (3aS,R-Biar)-3a... CAS#:61281-38-7 Schizandrin A
DownStream 0

Dibenzo[a,c]cyclooctene-3,10-diol, 5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-, (6R,7S)-

(-)-gomisin J

(6R,7S)-1,2,11,12-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene-3,10-diol

UNII:X13A57600T

6(S),7(R)-Dibenzo(a,c)cyclooctene-3,10-diol,5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl

Dibenzo(a,c)cyclooctene-3,10-diol,5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-,stereoisomer

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Gomisin J
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gomisin J
Price: ￥4000.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Gomisin J
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.