SirT1 enhancer A03
Modify Date: 2025-09-10 11:41:05
SirT1 enhancer A03 structure
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Common Name | SirT1 enhancer A03 | ||
|---|---|---|---|---|
| CAS Number | 66171-75-3 | Molecular Weight | 255.740 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 335.1±22.0 °C at 760 mmHg | |
| Molecular Formula | C13H18ClNO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 156.5±22.3 °C | |
Use of SirT1 enhancer A03SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity |
| Name | (S)-alaproclate |
|---|---|
| Synonym | More Synonyms |
| Description | SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity |
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| References | References 1. Campagna J, et al. Sci Rep. 2018 Dec 4;8(1):17574. View Related Products by Target Sirtuin |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 335.1±22.0 °C at 760 mmHg |
| Molecular Formula | C13H18ClNO2 |
| Molecular Weight | 255.740 |
| Flash Point | 156.5±22.3 °C |
| Exact Mass | 255.102600 |
| LogP | 2.93 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.528 |
| L-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester |
| (S)-alaproclate |
| DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester |
| 1-(4-chlorophenyl)-2-methylpropan-2-yl L-alaninate |
| 1-(4-Chlorophenyl)-2-methyl-2-propanyl L-alaninate |