PPM-18

Modify Date: 2024-01-03 17:45:14

PPM-18 structure	Common Name	PPM-18
	CAS Number	65240-86-0	Molecular Weight	277.274
	Density	1.4±0.1 g/cm3	Boiling Point	517.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	208.2±30.3 °C

Use of PPM-18

PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2].

Name	N-(1,4-dioxonaphthalen-2-yl)benzamide
Synonym	More Synonyms

Description	PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
References	[1]. S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9. [2]. Huiai Lu, et al. PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways. Front Pharmacol. 2021 Jul 9;12:684915.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

References

[1]. S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9.

[2]. Huiai Lu, et al. PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways. Front Pharmacol. 2021 Jul 9;12:684915.

Density	1.4±0.1 g/cm3
Boiling Point	517.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₁NO₃
Molecular Weight	277.274
Flash Point	208.2±30.3 °C
Exact Mass	277.073883
PSA	63.24000
LogP	2.09
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.667

1,4-Naphthalene...

CAS#:2348-81-4

Benzoyl chloride

CAS#:98-88-4

~38%

PPM-18

CAS#:65240-86-0

Literature: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT; CHOU, C., James; CHAN, Sherine, S.; RAHN, Jennifer, J.; JOSEY, Benjamin, J. Patent: WO2014/74976 A1, 2014 ; Location in patent: Paragraph 00239 ;

1,4-naphthoquinone

CAS#:130-15-4

PPM-18

CAS#:65240-86-0

Literature: Josey, Benjamin J.; Inks, Elizabeth S.; Wen, Xuejun; Chou, C. James Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 1007 - 1022

Precursor 3
CAS#:2348-81-4 1,4-Naphthalene... CAS#:98-88-4 Benzoyl chloride CAS#:130-15-4 1,4-naphthoquinone
DownStream 0

Benzamide, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-

2-benzoylamino-1,4-naphthoquinone

ppm-18

N-(1,4-Dioxo-1,4-dihydro-2-naphthalenyl)benzamide

2-Benzamino-1,4-naphthochinon

DC Chemicals Limited
China
Product Name: NQN-1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzamide,N-(1,4-dihydro-1,4-dioxo-2- naphthalenyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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PPM-18

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