oxprenolol
Modify Date: 2024-01-11 11:28:47
oxprenolol structure
|
Common Name | oxprenolol | ||
|---|---|---|---|---|
| CAS Number | 6452-71-7 | Molecular Weight | 265.34800 | |
| Density | 1.0479 (rough estimate) | Boiling Point | 408.57°C (rough estimate) | |
| Molecular Formula | C15H23NO3 | Melting Point | 78-80° | |
| MSDS | N/A | Flash Point | N/A | |
Use of oxprenololOxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1]. |
| Name | 1-(2-allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane |
|---|---|
| Synonym | More Synonyms |
| Description | Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1]. |
|---|---|
| Related Catalog | |
| Target |
β-adrenoceptor:7.10 nM (Ki) |
| In Vitro | Oxprenolol is lipophilic[3]. Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10-3 cm/h across abdominal human skin[3]. |
| In Vivo | Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade together with peak plasma drug levels within the normal clinical range[2]. Animal Model: Male rats (230 to 300 g body wt) of the Wistar strain[2] Dosage: 200 mg/kg Administration: Administered orally; daily for 3 weeks Result: This dosage produced effective beta-blockade. |
| References |
| Density | 1.0479 (rough estimate) |
|---|---|
| Boiling Point | 408.57°C (rough estimate) |
| Melting Point | 78-80° |
| Molecular Formula | C15H23NO3 |
| Molecular Weight | 265.34800 |
| Exact Mass | 265.16800 |
| PSA | 50.72000 |
| LogP | 2.38000 |
| Index of Refraction | 1.5000 (estimate) |
| 2-PROPANOL,1-[(1-METHYLETHYL)AMINO]-3-[2-(2-PROPEN-1-YLOXY)PHENOXY]- |
| Oxprenolol |