Ursodeoxycholic acid-13C

Modify Date: 2024-01-02 12:31:15

Ursodeoxycholic acid-13C structure	Common Name	Ursodeoxycholic acid-13C
	CAS Number	63296-46-8	Molecular Weight	393.56
	Density	1.1±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₃₁₃CH₄₀O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ursodeoxycholic acid-13C

Ursodeoxycholic acid-13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

Name	(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Synonym	More Synonyms

Description	Ursodeoxycholic acid-13C is the 13C labeled Ursodeoxycholic acid. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Signaling Pathways >> GPCR/G Protein >> GPCR19
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Jackson H, et al. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7. [3]. Kumar D, et al. Use of ursodeoxycholic acid in liver diseases. J Gastroenterol Hepatol. 2001 Jan;16(1):3-14. [4]. Biao Nie, et al. Specific Bile Acids Inhibit Hepatic Fatty Acid Uptake in Mice. Hepatology. 2012 Oct;56(4):1300-10.

Density	1.1±0.1 g/cm3
Molecular Formula	C₂₃₁₃CH₄₀O₄
Molecular Weight	393.56
Exact Mass	393.296021
PSA	77.76000
LogP	4.47790
Index of Refraction	1.543

Cholan-24-oic-24-C acid, 3,7-dihydroxy-, (3α,5β,7β)-

<24-13C>-Chenodeoxycholsaeure

(3α,5β,7β)-3,7-Dihydroxy(24-C)cholan-24-oic acid

DC Chemicals Limited
China
Product Name: Ursodeoxycholic acid-13C
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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