OXSI-2
Modify Date: 2025-08-31 23:00:47
OXSI-2 structure
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Common Name | OXSI-2 | ||
|---|---|---|---|---|
| CAS Number | 622387-85-3 | Molecular Weight | 353.395 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H15N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OXSI-2OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2]. |
| Name | 3-[(1-methylindol-3-yl)methylidene]-2-oxo-1H-indole-5-sulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2]. |
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| Related Catalog | |
| In Vitro | OXSI-2 (2 μM) completely inhibits Convulxin-induced platelet aggregation and shape change. OXSI-2 (2 μM) also completely blocks GPVI-mediated dense granule release. OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM[1]. Adaptor protein LAT is a known substrate of Syk Kinase. OXSI-2 completely inhibits LAT Y191 phosphorylation. OXSI-2 inhibits Syk mediated events in platelets[1]. OXSI-2 (2 μM) inhibits inflammasome assembly, caspase-1 activation, IL-1β processing and release, mitochondrial ROS generation, and pyroptotic cell death[2]. Western Blot Analysis[1] Cell Line: Aspirin-treated, washed human platelets Concentration: 2 μM Incubation Time: Result: Completely inhibited Syk-mediated LAT Y191 phosphorylation. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H15N3O3S |
| Molecular Weight | 353.395 |
| Exact Mass | 353.083405 |
| PSA | 102.57000 |
| LogP | 2.55 |
| Index of Refraction | 1.730 |
| 1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-, (3Z)- |
| 3-(1-Methylindol-3-ylmethylene)-2-oxo-2,3-dihydroindole-5-sulfonic acid amide |
| oxsi 2 |
| (3Z)-3-[(1-Methyl-1H-indol-3-yl)methylene]-2-oxo-5-indolinesulfonamide |
| in1070 |
| (3Z)-3-[(1-methyl-1H-indol-3-yl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide |