SM 16

Modify Date: 2024-01-10 19:50:00

SM 16 structure	Common Name	SM 16
	CAS Number	614749-78-9	Molecular Weight	430.5
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₆N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SM 16

SM 16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.

Name	SM 16

Description	SM 16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Research Areas >> Inflammation/Immunology Research Areas >> Cancer Research Areas >> Cardiovascular Disease
Target	ALK5[1]
References	[1]. Suzuki E, et al. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 2007 Mar 1;67(5):2351-9. [2]. Fu K, et al. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. [3]. Engebretsen KV, et al. Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. J Mol Cell Cardiol. 2014 Nov;76:148-57.

Molecular Formula	C₂₅H₂₆N₄O₃
Molecular Weight	430.5
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: SM16
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥1980/10 mM * 1 mL in DMSO

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