TRIPELENNAMINE CITRATE

Modify Date: 2025-10-06 14:52:23

TRIPELENNAMINE CITRATE structure	Common Name	TRIPELENNAMINE CITRATE
	CAS Number	6138-56-3	Molecular Weight	447.48200
	Density	N/A	Boiling Point	387.8ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₉N₃O₇	Melting Point	106-110°
	MSDS	N/A	Flash Point	188.3ºC

Use of TRIPELENNAMINE CITRATE

Tripelennamine citrate, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine citrate lessens the allergic response of the organism caused by histamine. Tripelennamine citrate can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3].

Name	N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine,2-hydroxypropane-1,2,3-tricarboxylic acid
Synonym	More Synonyms

Description	Tripelennamine citrate, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine citrate lessens the allergic response of the organism caused by histamine. Tripelennamine citrate can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
References	[1]. Manohar M, et al. H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds. J Appl Physiol. 2002 Apr;92(4):1515-23. [2]. Wasfi IA, et al. Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23(3):145-52. [3]. Yeh SY, et al. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76.

Boiling Point	387.8ºC at 760 mmHg
Melting Point	106-110°
Molecular Formula	C₂₂H₂₉N₃O₇
Molecular Weight	447.48200
Flash Point	188.3ºC
Exact Mass	447.20100
PSA	151.50000
LogP	1.40130
InChIKey	GGRBYIUPUOYRLQ-UHFFFAOYSA-N
SMILES	CN(C)CCN(Cc1ccccc1)c1ccccn1.O=C(O)CC(O)(CC(=O)O)C(=O)O

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US2950000

CAS REGISTRY NUMBER :: 6138-56-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H21-N3.C6-H8-O7

MOLECULAR WEIGHT :: 447.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 6168 ug/kg/12H

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions

REFERENCE :: CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 16,331,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80566 No. of Facilities: 460 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 3946 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80566 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1957 (estimated) No. of Female Employees: 1888 (estimated)

RIDADR	UN 3249
Packaging Group	III
Hazard Class	6.1(b)

Pyridine,2-(benzyl(2-(dimethylamino)ethyl)amino)-,citrate (1:1)

Pyribenzamine citrate

EINECS 228-121-6

Tripelennamine citrate

1,2-Ethanediamine,N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

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TRIPELENNAMINE CITRATE

Use of TRIPELENNAMINE CITRATE

Names