| Description |
Tiopinac is a highly potent anti-inflammatory, analgesic and anti-pyretic agent.
|
| Related Catalog |
|
| In Vivo |
Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1].
|
| Animal Admin |
Female rats, 160-180 g, receive 0.1 mL of a suspension in mineral oil of heatkilled M. butyricum (10 mg/mL) by means of two intradermal injections (0.05 mL each) into the proximal 1/4 of the tail on day 0. When the test agent is studied for its activity versus the development of the arthritic syndrome, it is administered p.o. (0.5 mL vehicle/dose) twice each day (at 9 a.m. and 4 p.m.) for 17 days, beginning on day 1. On day 18 the intensity of the swelling of the four foot pads and tail is determined blindly utilizing a scoring system in which the swelling in the four paws is scored 0-4 for each paw and the tail swelling is scored 0-3. The total maximum score is 19. The body weights and the weights of both hind paws are obtained. This procedure is a modification of a system initially described by PEARSON.
|
| References |
[1]. Rooks WH 2nd, et al. The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac). Agents Actions. 1980 Jun;10(3):266-73.
|
![methyl 6,11 -dihydrodibenzo-[b.e.]-thiepin-11 -one-3 -acetate Structure](https://image.chemsrc.com/caspic/147/61220-68-6.png)
CAS#:61220-68-6![6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetonitrile Structure](https://image.chemsrc.com/caspic/303/64976-83-6.png)
CAS#:64976-83-6![potassium 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetate Structure](https://image.chemsrc.com/caspic/499/61220-81-3.png)
CAS#:61220-81-3
CAS#:83794-93-8
CAS#:4025-64-3
CAS#:65-85-0
CAS#:83794-86-9
CAS#:4869-59-4
CAS#:83794-87-0
CAS#:83794-89-2