MK-0773
Modify Date: 2024-01-02 19:35:17
MK-0773 structure
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Common Name | MK-0773 | ||
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| CAS Number | 606101-58-0 | Molecular Weight | 479.590 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 754.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C27H34FN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 409.9±32.9 °C | |
Use of MK-0773MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM. |
| Name | (1S,3aS,3bS,5aR,9aS,9bS,11aS)-8-fluoro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide |
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| Synonym | More Synonyms |
| Description | MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM. |
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| Related Catalog | |
| Target |
IC50: 6.6 nM (AR) |
| In Vitro | The IC50 of MK-0773 binding to AR is increased 3.5-fold in the presence of 25% rat serum and 13-fold in the presence of 25% human serum, indicating that it binds to serum proteins. The affinity of MK-0773 for AR across species is evaluated using COS cells transfected with AR, and IC50 values are very similar in four species (rat, 0.50 nM; dog, 0.55 nM; rhesus, 0.45 nM; human, 0.65 nM)[1]. |
| In Vivo | MK-0773 (6 and 80 mg/kg, s.c.) produces exposure-related stimulatory effects on cortical BFR and LBM in the OVX rat model. MK-0773 (5, 15, and 80 mg/kg, s.c.) increases seminal vesicle weights, and has reduced effects on the prostate. The partial agonism and tissue selectivity of MK-0773 does not translate into differential effects on lipid metabolism in OVX rats[1]. |
| Animal Admin | Rats: Prostate and seminal vesicles are studied in 3-4-month-old 250-300-g rats after orchidectomy (ORX). Nine days after surgery, animals are injected (subcutaneously) daily with test compounds for 17 days, and the weight of the seminal vesicles (SVs) is compared with ORX rats treated with vehicle or DHT as a positive control. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 754.2±60.0 °C at 760 mmHg |
| Molecular Formula | C27H34FN5O2 |
| Molecular Weight | 479.590 |
| Flash Point | 409.9±32.9 °C |
| Exact Mass | 479.269653 |
| PSA | 94.47000 |
| LogP | 3.17 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.632 |
| Storage condition | 2-8℃ |
| mk 0773 |
| (4aS,4bS,6aS,7S,9aS,9bS,11aR)-3-Fluoro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-1,4a,6a-trimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide |
| 1H-Indeno[5,4-f]quinoline-7-carboxamide, 3-fluoro-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-1,4a,6a-trimethyl-2-oxo-, (4aS,4bS,6aS,7S,9aS,9bS,11aR)- |
| unii-5730vnw22x |
| MK-0773 |