TY-51469
Modify Date: 2025-12-01 13:01:39
TY-51469 structure
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Common Name | TY-51469 | ||
|---|---|---|---|---|
| CAS Number | 603987-59-3 | Molecular Weight | 526.60 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H15FN2O6S4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TY-51469TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively. |
| Name | TY-51469 |
|---|
| Description | TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively. |
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| Related Catalog | |
| Target |
IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1] |
| In Vivo | TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2]. |
| Animal Admin | Rats[1] The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1]. Mice[1] the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2]. |
| References |
| Molecular Formula | C20H15FN2O6S4 |
|---|---|
| Molecular Weight | 526.60 |
| InChIKey | CBRCULCCRGSSLB-UHFFFAOYSA-N |
| SMILES | Cc1c(S(=O)(=O)Nc2ccc(-c3nc(C(=O)O)cs3)cc2S(C)(=O)=O)sc2ccc(F)cc12 |