(−)-trans-Δ8-tetrahydrocannabinol

(−)-trans-Δ8-tetrahydrocannabinol Structure
(−)-trans-Δ8-tetrahydrocannabinol
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Common Name (−)-trans-Δ8-tetrahydrocannabinol
CAS Number 5957-75-5 Molecular Weight 314.462
Density 1.0±0.1 g/cm3 Boiling Point 383.5±42.0 °C at 760 mmHg
Molecular Formula C21H30O2 Melting Point N/A
MSDS N/A Flash Point 144.5±22.1 °C
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

 Names

Name 8-Tetrahydro Cannabinol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 383.5±42.0 °C at 760 mmHg
Molecular Formula C21H30O2
Molecular Weight 314.462
Flash Point 144.5±22.1 °C
Exact Mass 314.224579
PSA 29.46000
LogP 7.53
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.529

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HP8400000
CHEMICAL NAME :
6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-3-pentyl-6,6,9-trimethyl-, trans(-)-
CAS REGISTRY NUMBER :
5957-75-5
BEILSTEIN REFERENCE NO. :
0023921
LAST UPDATED :
199612
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C21-H30-O2
MOLECULAR WEIGHT :
314.51
WISWESSER LINE NOTATION :
T B666 HO MU&TTJ CQ E5 I1 I1 M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - analgesia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
97 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - analgesia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>3150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
59500 mg/kg/17W-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - aggression Related to Chronic Data - death
TYPE OF TEST :
DNA inhibition

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 17,703,1977

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Hazard Codes F: Flammable;
Risk Phrases 11-39/23/24/25-23/24/25
Safety Phrases 7-16-36/37-45
RIDADR UN 1170

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 Synonyms

6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR,10aR)-
D8-THC
δ6-THC
δ8-Tetrahydrocannabinol
δ-8-THC
(6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
δ8-THC
(-)-D6-3,4-trans-Tetrahydro-6,6,9-tri methyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol\
6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
D6-THC
6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-