midazolam maleate

Modify Date: 2024-01-03 02:31:46

midazolam maleate Structure
midazolam maleate structure
Common Name midazolam maleate
CAS Number 59467-94-6 Molecular Weight 441.840
Density N/A Boiling Point 496.9ºC at 760 mmHg
Molecular Formula C22H17ClFN3O4 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name (Z)-but-2-enedioic acid,8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 496.9ºC at 760 mmHg
Molecular Formula C22H17ClFN3O4
Molecular Weight 441.840
Exact Mass 441.089172
PSA 104.78000
LogP 3.47160
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI2922200
CAS REGISTRY NUMBER :
59467-94-6
LAST UPDATED :
199707
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H13-Cl-F-N3.C4-H4-O4
MOLECULAR WEIGHT :
441.87
WISWESSER LINE NOTATION :
T B576 BN DN HN GHJ C1 IR BF& LG &QV1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2180,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
86 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2180,1981

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S36
RIDADR UN 3249
WGK Germany 3
RTECS NI2922200
Packaging Group III
Hazard Class 6.1(b)

 Articles3

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PLoS ONE 5 , e12477, (2010)

The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1be...

Midazolam produces vasodilation by mixed endothelium-dependent and -independent mechanisms.

Anesth. Analg. 78 , 710, (1994)

Aortic rings were obtained from rat thoracic aorta and studied in vitro with and without functionally intact endothelium to determine whether "the mechanism" requires endothelium [or endothelium-deriv...

Opposite effects of midazolam and beta-carboline-3-carboxylate ethyl ester on the release of dopamine from rat nucleus accumbens measured by in vivo microdialysis.

Eur. J. Pharmacol. 261 , 65, (1994)

This report describes the effects of midazolam and beta-carboline-3-carboxylate ethyl ester (beta-CCE) on extracellular concentrations of dopamine in the nucleus accumbens of freely moving rats measur...

 Synonyms

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine monomaleate
Midazolam maleate salt
Dormicum
midazolam maleate
Ro 21-3981/001
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-, (2Z)-2-butenedioate (1:1)
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate
MFCD00941440
EINECS 261-775-0
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (2Z)-2-butenedioate (1:1)
Ro-21-3981/001
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine monomaleate
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (2Z)-but-2-enedioate (1:1)
Dormicum maleate
Hypnovel
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine maleate salt
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