(Val5)-Angiotensin II

Modify Date: 2024-01-02 15:22:46

(Val5)-Angiotensin II Structure
(Val5)-Angiotensin II structure
Common Name (Val5)-Angiotensin II
CAS Number 58-49-1 Molecular Weight 1032.15
Density N/A Boiling Point N/A
Molecular Formula C49H69N13O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Val5)-Angiotensin II


Angiotensin II 5-valine is an agonist of angiotensin receptor.

 Names

Name [Val5] Angiotensin II, human
Synonym More Synonyms

 (Val5)-Angiotensin II Biological Activity

Description Angiotensin II 5-valine is an agonist of angiotensin receptor.
Related Catalog
Target

Angiotensin receptor[1].

In Vivo By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].
Animal Admin Rats[1] Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1].
References

[1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.

 Chemical & Physical Properties

Molecular Formula C49H69N13O12
Molecular Weight 1032.15
PSA 443.64000
LogP 2.77030
Storage condition -20°C

 Synonyms

DRVYVHPF
(5-L-Val)-Angiotensin II
Angiotensin Acetate
L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
<Val5>-angiotensin II
ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
[Asp(1),Val(5)]angiotensin II
H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH
[VAL5] ANGIOTENSIN II HUMAN
ANGIOTENSIN II,5-L-VALINE
[val5]-angiotensin ii acetate hydrate
Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Angiotensin II 5-valine