(Val5)-Angiotensin II
Modify Date: 2024-01-02 15:22:46
(Val5)-Angiotensin II structure
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Common Name | (Val5)-Angiotensin II | ||
|---|---|---|---|---|
| CAS Number | 58-49-1 | Molecular Weight | 1032.15 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C49H69N13O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Val5)-Angiotensin IIAngiotensin II 5-valine is an agonist of angiotensin receptor. |
| Name | [Val5] Angiotensin II, human |
|---|---|
| Synonym | More Synonyms |
| Description | Angiotensin II 5-valine is an agonist of angiotensin receptor. |
|---|---|
| Related Catalog | |
| Target |
Angiotensin receptor[1]. |
| In Vivo | By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1]. |
| Animal Admin | Rats[1] Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1]. |
| References |
| Molecular Formula | C49H69N13O12 |
|---|---|
| Molecular Weight | 1032.15 |
| PSA | 443.64000 |
| LogP | 2.77030 |
| Storage condition | -20°C |
| DRVYVHPF |
| (5-L-Val)-Angiotensin II |
| Angiotensin Acetate |
| L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE |
| <Val5>-angiotensin II |
| ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE |
| [Asp(1),Val(5)]angiotensin II |
| H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH |
| [VAL5] ANGIOTENSIN II HUMAN |
| ANGIOTENSIN II,5-L-VALINE |
| [val5]-angiotensin ii acetate hydrate |
| Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH |
| Angiotensin II 5-valine |