4-(2,2,2-trifluoroethoxy)aniline

Modify Date: 2024-01-02 09:06:57

4-(2,2,2-trifluoroethoxy)aniline Structure
4-(2,2,2-trifluoroethoxy)aniline structure
Common Name 4-(2,2,2-trifluoroethoxy)aniline
CAS Number 57946-61-9 Molecular Weight 191.15000
Density 1.286g/cm3 Boiling Point 227.3ºC at 760 mmHg
Molecular Formula C8H8F3NO Melting Point N/A
MSDS USA Flash Point 91.3ºC

 Names

Name 4-(2,2,2-trifluoroethoxy)aniline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.286g/cm3
Boiling Point 227.3ºC at 760 mmHg
Molecular Formula C8H8F3NO
Molecular Weight 191.15000
Flash Point 91.3ºC
Exact Mass 191.05600
PSA 35.25000
LogP 2.79110
Index of Refraction 1.48

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 4-(2,2,2-trifluoroethoxy)aniline
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H317:May cause an allergic skin reaction
P280:Wear protective gloves/protective clothing/eye protection/face protection

Section3. Composition/information on ingredients.
Ingredient name:4-(2,2,2-trifluoroethoxy)aniline
CAS number:57946-61-9

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C8H8F3NO
Molecular weight:191.2

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

HS Code 2922299090

 Synthetic Route

~99%

4-(2,2,2-trifluoroethoxy)aniline Structure

4-(2,2,2-triflu...

CAS#:57946-61-9

Literature: Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Brown, David L.; Carroll, Jeffery N.; Chen, Yiyuan; Fobian, Yvette M.; Freskos, John N.; Gasiecki, Alan F.; Grapperhaus, Margaret L.; Heintz, Robert M.; Hockerman, Susan L.; Kassab, Darren J.; Khanna, Ish K.; Kolodziej, Stephen A.; Massa, Mark A.; McDonald, Joseph J.; Mischke, Brent V.; Mischke, Deborah A.; Mullins, Patrick B.; Nagy, Mark A.; Norton, Monica B.; Rico, Joseph G.; Schmidt, Michelle A.; Stehle, Nathan W.; Talley, John J.; Vernier, William F.; Villamil, Clara I.; Wang, Lijuan J.; Wynn, Thomas A. Patent: US2005/9838 A1, 2005 ; Location in patent: Page 113 ; US 20050009838 A1

~%

4-(2,2,2-trifluoroethoxy)aniline Structure

4-(2,2,2-triflu...

CAS#:57946-61-9

Literature: US2002/169159 A1, ; US 20020169159 A1

~%

Detail
Literature: US4968829 A1, ;

~%

4-(2,2,2-trifluoroethoxy)aniline Structure

4-(2,2,2-triflu...

CAS#:57946-61-9

Literature: US2012/289549 A1, ; US 20120289549 A1

~%

4-(2,2,2-trifluoroethoxy)aniline Structure

4-(2,2,2-triflu...

CAS#:57946-61-9

Literature: Synthetic Communications, , vol. 14, # 7 p. 621 - 630

~%

4-(2,2,2-trifluoroethoxy)aniline Structure

4-(2,2,2-triflu...

CAS#:57946-61-9

Literature: Synthetic Communications, , vol. 14, # 7 p. 621 - 630

 Customs

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

MFCD00077606