R 112
Modify Date: 2025-09-18 11:03:48
R 112 structure
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Common Name | R 112 | ||
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| CAS Number | 575474-82-7 | Molecular Weight | 312.29800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H13FN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of R 112R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM. IC50 value: 226 nM [1]Target: Sykin vitro: R112 blocks leukotriene C4 production and all proinflammatory cytokines tested. Its onset of action was immediate, and the inhibition was reversible. R112 is able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 potently, completely, and rapidly abrogated all mast cell activation cascades triggered by IgE receptor cross-linking.[1] |
| Name | 3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol |
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| Synonym | More Synonyms |
| Description | R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM. IC50 value: 226 nM [1]Target: Sykin vitro: R112 blocks leukotriene C4 production and all proinflammatory cytokines tested. Its onset of action was immediate, and the inhibition was reversible. R112 is able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 potently, completely, and rapidly abrogated all mast cell activation cascades triggered by IgE receptor cross-linking.[1] |
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| Related Catalog | |
| References |
| Molecular Formula | C16H13FN4O2 |
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| Molecular Weight | 312.29800 |
| Exact Mass | 312.10200 |
| PSA | 93.53000 |
| LogP | 3.00900 |
| Appearance of Characters | offwhite solid |
| InChIKey | TVKGTSHBQZEFEE-UHFFFAOYSA-N |
| SMILES | Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1 |
| R 112 |
| R112 |