KRH-1636
Modify Date: 2024-09-15 18:08:38
KRH-1636 structure
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Common Name | KRH-1636 | ||
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| CAS Number | 568526-77-2 | Molecular Weight | 551.682 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C32H37N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRH-1636A potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5; completely inhibits X4 HIV-1 (IIIB strain) replication in MT-4 cells with EC50 of 19.3 nM and EC90 of 47.8 nM, without cytotoxic concentration (CC50>400 uM), also has effectivity against HTLV-IIIB and three clinical isolates in PBMCs including YU-6 (EC50=46 nM), but not R5 HIV-1, YU-1, YU-2; selectively blocks CXCR4-mediated Ca2+ signaling, blocks X4 HIV-1 replication in human PBL/SCID mice. |
| Name | N-[(2S)-5-[(Diaminomethylene)amino]-1-{[(1S)-1-(1-naphthyl)ethyl]amino}-1-oxo-2-pentanyl]-4-{[(2-pyridinylmethyl)amino]methyl}benzamide |
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| Synonym | More Synonyms |
| Description | A potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5; completely inhibits X4 HIV-1 (IIIB strain) replication in MT-4 cells with EC50 of 19.3 nM and EC90 of 47.8 nM, without cytotoxic concentration (CC50>400 uM), also has effectivity against HTLV-IIIB and three clinical isolates in PBMCs including YU-6 (EC50=46 nM), but not R5 HIV-1, YU-1, YU-2; selectively blocks CXCR4-mediated Ca2+ signaling, blocks X4 HIV-1 replication in human PBL/SCID mice. |
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| References | References 1. Ichiyama K, et al. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4185-90. 2. Murakami T, et al. Antimicrob Agents Chemother. 2009 Jul;53(7):2940-8. 3. Zachariassen ZG, et al. J Med Chem. 2015 Oct 22;58(20):8141-53. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Density | 1.2±0.1 g/cm3 |
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| Molecular Formula | C32H37N7O2 |
| Molecular Weight | 551.682 |
| Exact Mass | 551.300903 |
| LogP | 2.96 |
| Index of Refraction | 1.643 |
| Benzamide, N-[(1S)-4-[(diaminomethylene)amino]-1-[[[(1S)-1-(1-naphthalenyl)ethyl]amino]carbonyl]butyl]-4-[[(2-pyridinylmethyl)amino]methyl]- |
| N-[(2S)-5-[(Diaminomethylene)amino]-1-{[(1S)-1-(1-naphthyl)ethyl]amino}-1-oxo-2-pentanyl]-4-{[(2-pyridinylmethyl)amino]methyl}benzamide |