1H-Indole,1-(phenylmethyl)-3-[2-(4-pyridinyl)ethyl]-, hydrochloride (1:1)

MOLECULAR FORMULA :

C22-H20-N2.Cl-H

MOLECULAR WEIGHT :

348.90

WISWESSER LINE NOTATION :

T56 BNJ B1R& D2- DT6NJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

714 ug/kg/D

TOXIC EFFECTS :

Behavioral - antianxiety Vascular - BP elevation not characterized in autonomic section

REFERENCE :

AMCTAH Antibiotic Medicine and Clinical Therapy (New York). (New York, NY) V.3-8, 1956-61. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,521,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

520 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 125,122,1959

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

98 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 125,122,1959