Saikogenin D
Modify Date: 2025-08-26 11:55:46
Saikogenin D structure
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Common Name | Saikogenin D | ||
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| CAS Number | 5573-16-0 | Molecular Weight | 472.700 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 607.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C30H48O4 | Melting Point | 261-266 °C | |
| MSDS | N/A | Flash Point | 252.4±26.1 °C | |
Use of Saikogenin DSaikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2]. |
| Name | 3β,16α,23,28-Tetrahydroxyoleana-11(12),13(18)-diene |
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| Synonym | More Synonyms |
| Description | Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2]. |
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| Related Catalog | |
| In Vitro | Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1]. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 607.4±55.0 °C at 760 mmHg |
| Melting Point | 261-266 °C |
| Molecular Formula | C30H48O4 |
| Molecular Weight | 472.700 |
| Flash Point | 252.4±26.1 °C |
| Exact Mass | 472.355255 |
| PSA | 80.92000 |
| LogP | 5.38 |
| Vapour Pressure | 0.0±3.9 mmHg at 25°C |
| Index of Refraction | 1.586 |
| InChIKey | QGNVMEXLLPGQEV-IULQVHCXSA-N |
| SMILES | CC1(C)CCC2(CO)C(=C3C=CC4C5(C)CCC(O)C(C)(CO)C5CCC4(C)C3(C)CC2O)C1 |
| (3β,16α)-Oleana-11,13(18)-diene-3,16,23,28-tetrol |
| Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16α)- |
| Saikogenin D |