Avarol

Modify Date: 2024-01-06 15:47:56

Avarol structure	Common Name	Avarol
	CAS Number	55303-98-5	Molecular Weight	314.46200
	Density	1.055g/cm3	Boiling Point	449.5ºC at 760 mmHg
	Molecular Formula	C₂₁H₃₀O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	200ºC

Use of Avarol

Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.

Name	2-[[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]benzene-1,4-diol
Synonym	More Synonyms

Density	1.055g/cm3
Boiling Point	449.5ºC at 760 mmHg
Molecular Formula	C₂₁H₃₀O₂
Molecular Weight	314.46200
Flash Point	200ºC
Exact Mass	314.22500
PSA	40.46000
LogP	5.43910
Index of Refraction	1.552

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9026700

CHEMICAL NAME :: 1,4-Benzenediol, 2-((1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl- 1-naphthalenyl) methyl)-, (1R-(1-alpha,2-beta,4a-beta,8a-alpha))-

CAS REGISTRY NUMBER :: 55303-98-5

LAST UPDATED :: 199406

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H30-O2

MOLECULAR WEIGHT :: 314.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 269 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 3800 nmol/L

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,473,1986

Precursor 6
CAS#:252577-53-0 2-(pyridin-2-yl... CAS#:55303-99-6 Avarone CAS#:184485-49-2 (4aS,5R,6S,8aS)... CAS#:33524-31-1 2,5-dimethoxybe...
CAS#:60732-17-4 2,5-Dimethoxybe... CAS#:41722-49-0 (8aS)-5,8a-dime...
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