PNRI-299
Modify Date: 2025-08-27 15:38:06
PNRI-299 structure
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Common Name | PNRI-299 | ||
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| CAS Number | 550368-41-7 | Molecular Weight | 401.37 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H15N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PNRI-299PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20 uM without affecting NF-kappaB transcription (up to 200 uM) or thioredoxin (up to 200 uM).IC50 value: 20 uM [1]Target: AP-1 inhibitorin vitro: PNRI-299 specifically reacts with Ref-1, inhibits AP-1 transcription, and overexpression of the molecular target. Ref-1 attenuates PNRI-299 inhibition of AP-1 transcription. PNRI-299 interacts with the redox nucleophile Cys-65, to aid in the interpretation of structure activity relationships (SARs).in vivo: Treatment with PNRI-299 significantly decreased the influx of eosinophils, monocytes, and macrophages (no significant reduction of lymphocytes was observed) into the lung interstitium and bronchoalveolar lavage fluid, and airway mucus and edema observed in OVA-treated mice.PNRI-299 reduces the pathophysiological responses seen in this murine model of allergic asthma [1]. PNRI-299 had no effects on the inflammatory changes or lethality induced by I/R injury [2]. |
| Name | PNRI-299 |
|---|---|
| Synonym | More Synonyms |
| Description | PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20 uM without affecting NF-kappaB transcription (up to 200 uM) or thioredoxin (up to 200 uM).IC50 value: 20 uM [1]Target: AP-1 inhibitorin vitro: PNRI-299 specifically reacts with Ref-1, inhibits AP-1 transcription, and overexpression of the molecular target. Ref-1 attenuates PNRI-299 inhibition of AP-1 transcription. PNRI-299 interacts with the redox nucleophile Cys-65, to aid in the interpretation of structure activity relationships (SARs).in vivo: Treatment with PNRI-299 significantly decreased the influx of eosinophils, monocytes, and macrophages (no significant reduction of lymphocytes was observed) into the lung interstitium and bronchoalveolar lavage fluid, and airway mucus and edema observed in OVA-treated mice.PNRI-299 reduces the pathophysiological responses seen in this murine model of allergic asthma [1]. PNRI-299 had no effects on the inflammatory changes or lethality induced by I/R injury [2]. |
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| Related Catalog | |
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| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C21H15N5O4 |
| Molecular Weight | 401.37 |
| LogP | 0.22 |
| Index of Refraction | 1.712 |
| Storage condition | 2-8℃ |
| 1H-[1,2,4]Triazolo[1,2-a]pyridazine-5-carboxamide, 2,3,7,8-tetrahydro-2-(3-methylphenyl)-1,3,7-trioxo-N-(phenylmethyl)- |
| N-Benzyl-2-(3-methylphenyl)-1,3,7-trioxo-2,3,7,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxamide |
| 2WW6I6D1Z1 |