Doxorubicinol

Modify Date: 2024-01-02 06:55:12

Doxorubicinol structure	Common Name	Doxorubicinol
	CAS Number	54193-28-1	Molecular Weight	545.54
	Density	1.6±0.1 g/cm3	Boiling Point	828.7±65.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₃₁NO₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	455.0±34.3 °C

Use of Doxorubicinol

Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

Name	adriamycinol
Synonym	More Synonyms

Description	Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	Doxorubicinol 抑制分离的乳头肌的舒张功能（即增加静息压）[1]。 Doxorubicinol 在显著降低舒张功能的浓度下，阿霉素几乎完全消除钙泵活性[1]。 Doxorubicinol 抑制 Ca2+ 刺激的骨骼肌肌浆网的 ATP 酶活性，并消除犬和兔心脏制备物中肌膜的 Na+/K+-ATP 酶活性[1]。 Doxorubicinol 抑制 PANC-1 细胞的增殖，IC50 值为 35.4 μM，PD PaCa 细胞的 IC50 值为 44.5 μM，WD PaCa 细胞的 IC50 值为 49.5 μM[1]。
References	[1]. Olson RD, et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A. 1988 May;85(10):3585-9.

Density	1.6±0.1 g/cm3
Boiling Point	828.7±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₁NO₁₁
Molecular Weight	545.54
Flash Point	455.0±34.3 °C
Exact Mass	545.189697
PSA	209.23000
LogP	2.01
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.717

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9326000

CHEMICAL NAME :: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-amino-2,3,6-trideoxy-alpha -L-lyxo- hexopyranosyl)oxy)-8-(1,2-dihdyroxyethyl)-1-methoxy-6 ,8,11-trihydroxy-, (8S-(8-alpha,8(R*), 10-alpha))-

CAS REGISTRY NUMBER :: 54193-28-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H31-N-O11

MOLECULAR WEIGHT :: 545.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 26900 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1006,1981

Precursor 0
DownStream 1
CAS#:23214-92-8 Doxorubicin hyd...

14-hydroxydaunomycinone

adriamycinaglycone

8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione

doxorubicin aglycone

Doxorubicinol

Adriamycin-aglycon

(1S,3S)-3-[(1S)-1,2-Dihydroxyethyl]-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

Epirubicin aglycone

doxorubicin hydroxyaglycone

5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-

Epirubicin aglycon

Doxorubicinone

13-dihydrodoxorubicin

DC Chemicals Limited
China
Product Name: 13-Dihydrodoxorubicin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Doxorubicinol Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Precursor & DownStream

Synonyms