N4-Bz-2'-OMe-rC

Modify Date: 2025-08-26 11:49:57

N4-Bz-2'-OMe-rC Structure
N4-Bz-2'-OMe-rC structure
Common Name N4-Bz-2'-OMe-rC
CAS Number 52571-45-6 Molecular Weight 361.35
Density 1.49g/cm3 Boiling Point N/A
Molecular Formula C17H19N3O6 Melting Point 174-175ºC
MSDS N/A Flash Point N/A

 Use of N4-Bz-2'-OMe-rC


N4-Benzoyl-2’-O-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

 Names

Name N4-Benzoyl-2'-O-methylcytidine
Synonym More Synonyms

 N4-Bz-2'-OMe-rC Biological Activity

Description N4-Benzoyl-2’-O-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
Related Catalog
References

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

 Chemical & Physical Properties

Density 1.49g/cm3
Melting Point 174-175ºC
Molecular Formula C17H19N3O6
Molecular Weight 361.35
Exact Mass 361.12700
PSA 122.91000
Appearance of Characters Powder | White to Pale Yellow
Index of Refraction 1.659
InChIKey LIZIIHWLABYQKD-XKVFNRALSA-N
SMILES COC1C(O)C(CO)OC1n1ccc(NC(=O)c2ccccc2)nc1=O

 Safety Information

Hazard Codes Xi

 Synthetic Route

~79%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

~56%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Gladkaya, V. A.; Levitskaya, Z. V.; Shalamai, A. S.; Usenko, L. S.; Dashevskaya, T. A. Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 488 - 492

~%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Isis Pharmceuticals, Inc. Patent: US5646265 A1, 1997 ; Title/Abstract Full Text Show Details ISIS Pharmaceuticals, Inc. Patent: US5914396 A1, 1999 ;

~%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

~%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

~%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Chavis, C.; Dumont, F.; Wightman, R. H.; Ziegler, J. C.; Imbach, J. L. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 202 - 206

~%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Gladkaya, V. A.; Levitskaya, Z. V.; Shalamai, A. S.; Usenko, L. S.; Dashevskaya, T. A. Chemistry of Natural Compounds, 1989 , vol. 25, # 4 p. 488 - 492

~%

N4-Bz-2'-OMe-rC Structure

N4-Bz-2'-OMe-rC

CAS#:52571-45-6

Literature: Metelev, Valerii G.; Krynetskaya, Natalya F.; Purmal, Andrei A.; Shabarova, Zoya A.; Tocik, Zdenek; et al. Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 11 p. 2781 - 2786

 Synonyms

N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
N4-Bz-2'-OMe-rC
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