Carubicin

Modify Date: 2024-01-02 14:50:39

Carubicin structure	Common Name	Carubicin
	CAS Number	50935-04-1	Molecular Weight	513.493
	Density	1.6±0.1 g/cm3	Boiling Point	750.6±60.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₂₇NO₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	407.7±32.9 °C

Use of Carubicin

Carubicin (Carminomycin) is a microbially-derived compound. Carubicin is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin has the potential for the research of cancer diseases[1][2].

Name	5,12-Naphthacenedione, 8-acetyl-10-[[3-amino-2,3,6-trideoxy-.α.-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)
Synonym	More Synonyms

Description	Carubicin (Carminomycin) is a microbially-derived compound. Carubicin is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin has the potential for the research of cancer diseases[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection
References	[1]. [1]Woldemichael GM, et al. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42.

Density	1.6±0.1 g/cm3
Boiling Point	750.6±60.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₇NO₁₀
Molecular Weight	513.493
Flash Point	407.7±32.9 °C
Exact Mass	513.163513
PSA	196.84000
LogP	3.54
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.727

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9293250

CHEMICAL NAME :: 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hex opyranosyl)oxy)- 7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)-

CAS REGISTRY NUMBER :: 50935-04-1

LAST UPDATED :: 199406

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C26-H27-N-O10

MOLECULAR WEIGHT :: 513.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7250 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 490 nmol/L

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1596,1981

N-(Trifluoroace...

CAS#:68594-06-9

Carubicin

CAS#:50935-04-1

Literature: Zabudkin, Alexander F.; Matvienko, Victor; Matveev, Alexey; Itkin, Aleksandr M. Patent: US2007/135624 A1, 2007 ; Location in patent: Page/Page column 2 ;

Precursor 1
CAS#:68594-06-9 N-(Trifluoroace...
DownStream 0

(1S,3S)-3-Acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

Carminomycin

(1S,3S)-3-Acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

Carminomycin I

Antibiotic R-588A

Carminomicin I

(1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside

Karminomitsin

5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)-

4-O-Demethyldaunorubicin

5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S,10S)-

Karminomycin

(8S-cis)-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione

Carubicin

DC Chemicals Limited
China
Product Name: Carubicin
Price: $500.0/10mg $900.0/25mg $1900.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Carminomicin I
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Carubicin

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