ISO-1

Modify Date: 2025-08-25 15:32:46

Use of ISO-1

ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

Name	methyl 2-[3-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,2-oxazolidin-5-yl]acetate
Synonym	More Synonyms

Description	ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82. [2]. Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4. [3]. Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142.

Description

ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

Density	1.3±0.1 g/cm3
Boiling Point	365.0±48.0 °C at 760 mmHg
Melting Point	114 °C
Molecular Formula	C₁₂H₁₃NO₄
Molecular Weight	235.236
Flash Point	174.6±29.6 °C
Exact Mass	235.084457
PSA	64.63000
LogP	0.89
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.582
InChIKey	AIXMJTYHQHQJLU-UHFFFAOYSA-N
SMILES	COC(=O)CC1CC(c2ccc(O)cc2)=NO1

HS Code	2934999090

Precursor 4
CAS#:1056465-52-1 1-(4-hydroxyphe... CAS#:109272-34-6 1-(4-hydroxyphe... CAS#:123-08-0 4-hydroxybenzal... CAS#:699-06-9 Benzaldehyde, 4...
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Methyl [3-(4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetate

UNII-7QFF3Z0V9X

MIF Antagonist,ISO-1

5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester

3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER

3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester

UNII:7QFF3Z0V9X

Macrophage Migration Inhibitory Factor Antagonist,ISO-1

ISO-1

Get all suppliers and price by the below link:

Price: $112/10mM*1mLinDMSO

Reference only. check more ISO-1 price