PA 452

Modify Date: 2025-08-26 09:56:02

PA 452 Structure
PA 452 structure
Common Name PA 452
CAS Number 457657-34-0 Molecular Weight 439.59
Density N/A Boiling Point N/A
Molecular Formula C26H37N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PA 452


PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development[1].

 Names

Name PA452

 PA 452 Biological Activity

Description PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development[1].
Related Catalog
Target

RXR

In Vitro PA452 inhibits the Troglitazone (TZ)-induced CK13 expression[2]. PA452 (0.01, 0.1, and 1 μM) inhibits RXR in normal human urothelial (NHU) cells[2].
References

[1]. Iwata M, et al. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int Immunol. 2003 Aug;15(8):1017-25.

[2]. Varley CL, et al. Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol. 2004 May;164(5):1789-98.

 Chemical & Physical Properties

Molecular Formula C26H37N3O3
Molecular Weight 439.59
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