TIE-2/VEGFR-2 kinase-IN-1

Modify Date: 2025-11-25 09:31:58

TIE-2/VEGFR-2 kinase-IN-1 structure	Common Name	TIE-2/VEGFR-2 kinase-IN-1
	CAS Number	453590-24-4	Molecular Weight	241.24500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₁N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TIE-2/VEGFR-2 kinase-IN-1

TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1].

Name	6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine
Synonym	More Synonyms

Description	TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
In Vitro	Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1]. Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.
References	[1]. Jerry Leroy Adams, et al. Furo-and thienopyrimidine derivatives as angiogenesis inhibitors. Patent WO2003022852.

Molecular Formula	C₁₃H₁₁N₃O₂
Molecular Weight	241.24500
Exact Mass	241.08500
PSA	74.17000
LogP	3.06180

(Z)-Methanimidi...

CAS#:77287-34-4

2-AMINO-5-(4-ME...

CAS#:26454-83-1

~66%

TIE-2/VEGFR-2 k...

CAS#:453590-24-4

Literature: SMITHKLINE BEECHAM CORPORATION Patent: WO2005/61516 A1, 2005 ; Location in patent: Page/Page column 17-19 ; WO 2005/061516 A1

PTP inhibitor 1

CAS#:2632-13-5

TIE-2/VEGFR-2 k...

CAS#:453590-24-4

Literature: Miyazaki, Yasushi; Matsunaga, Shinichiro; Tang, Jun; Maeda, Yutaka; Nakano, Masato; Philippe, Rocher J.; Shibahara, Megumi; Liu, Wei; Sato, Hideyuki; Wang, Liping; Nolte, Robert T. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 9 p. 2203 - 2207

2-(2-OXO-2-(4-M...

CAS#:26454-79-5

TIE-2/VEGFR-2 k...

CAS#:453590-24-4

Precursor 4
CAS#:77287-34-4 (Z)-Methanimidi... CAS#:26454-83-1 2-AMINO-5-(4-ME... CAS#:2632-13-5 PTP inhibitor 1 CAS#:26454-79-5 2-(2-OXO-2-(4-M...
DownStream 0

hms3303n07

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TIE-2/VEGFR-2 kinase-IN-1
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: TIE-2/VEGFR-2 kinase-IN-1
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥6630/10 mM * 1 mL in DMSO

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TIE-2/VEGFR-2 kinase-IN-1

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.