4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol

Modify Date: 2025-08-25 20:50:31

4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol Structure
4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol structure
Common Name 4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol
CAS Number 4371-34-0 Molecular Weight 246.25900
Density 1.36g/cm3 Boiling Point 501.6ºC at 760 mmHg
Molecular Formula C14H14O4 Melting Point N/A
MSDS N/A Flash Point 248.2ºC

 Use of 4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol


NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer[1].

 Names

Name 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol
Synonym More Synonyms

  Biological Activity

Description NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer[1].
Related Catalog
In Vitro NSC2805 has WWP2 inhibitory activity with an IC50 of 0.38 μM[1]. NSC2805 shows a significant reduction in activity for all three proteins (WWP2, WWP1 and Nedd4)[1]. NSC2805 can robustly inhibit WWP2-dependent PTEN ubiquitination[1].
References

[1]. Jessica E Watt, et al. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 3;24(67):17677-17680.

 Chemical & Physical Properties

Density 1.36g/cm3
Boiling Point 501.6ºC at 760 mmHg
Molecular Formula C14H14O4
Molecular Weight 246.25900
Flash Point 248.2ºC
Exact Mass 246.08900
PSA 80.92000
LogP 2.79280
Index of Refraction 1.675
InChIKey DSVRCBOSZSZMRX-UHFFFAOYSA-N
SMILES Cc1cc(O)c(-c2cc(O)c(C)cc2O)cc1O

 Safety Information

HS Code 2906299090

 Customs

HS Code 2906299090
Summary 2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

4.4'-Dimethyl-biphenyltetrol-(2.5.2'.5')
2.5.2'.5'-Tetraoxy-4.4'-dimethyl-diphenyl
2.5.2'.5'-Tetrahydroxy-4.4'-dimethyl-biphenyl
2.5.2'.5'-Tetraoxy-ditolyl-(4.4')
4,4'-dimethyl[1,1'-biphenyl]-2,2',5,5'-tetrol
4,4'-Dimethyl-biphenyl-2,5,2',5'-tetraol
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