Edratide
Modify Date: 2025-09-18 14:42:52
Edratide structure
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Common Name | Edratide | ||
|---|---|---|---|---|
| CAS Number | 433922-67-9 | Molecular Weight | 2309.53000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C111H149N27O28 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EdratideEdratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE)[1][2][3]. |
| Name | Edratide [INN] |
|---|---|
| Synonym | More Synonyms |
| Description | Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE)[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vivo | Edratide (20-50 µg; s.c.; once a week for 10 weeks) exerts beneficial effects on SLE is through regulation of gene expression[2]. Edratide (50 μg/mouse; s.c.; 10 weekly) reduces the rates of apoptosis and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL in SLE mouse[3]. Animal Model: 6-7 months female mice (with established SLE)[2] Dosage: 20-50 µg Administration: Subcutaneously injection; once a week for 10 weeks Result: Up-regulated the RNA transcripts of Tnfsf4, Il5ra, Zbtb20, Nid1, down-regulated the transcripts of Tfpi and S100a8. Animal Model: 7-8 months SLE-afflicted BWF1 female mice[3] Dosage: 50 μg/mouse Administration: S.c.; 10 weekly Result: Reduced apoptosis, down-regulated caspase-8 and caspase-3, and up-regulated Bcl-xL. |
| Molecular Formula | C111H149N27O28 |
|---|---|
| Molecular Weight | 2309.53000 |
| Exact Mass | 2308.11000 |
| PSA | 883.21000 |
| LogP | 5.62520 |
| InChIKey | VXXZQHUWZSRPAM-CDJUQFLLSA-N |
| SMILES | CCC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(CCCCN)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(CCC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)CN)C(C)CC)C(=O)NCC(=O)O |
| UNII-38PLP07BKC |
| Glycyl-L-tyrosyl-L-tyrosyl-L-tryptophyl-L-seryl-L-tryptophyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-prolyl-L-prolylglycyl-L-lysylglycyl-L-glutamyl-L-glutamyl-L-tryptophyl-L-isoleucylglycine |
| Edratide Acetate |