Clopirac

Modify Date: 2024-01-10 10:07:23

Clopirac Structure
Clopirac structure
Common Name Clopirac
CAS Number 42779-82-8 Molecular Weight 263.71900
Density 1.23g/cm3 Boiling Point 429.1ºC at 760mmHg
Molecular Formula C14H14ClNO2 Melting Point N/A
MSDS N/A Flash Point 213.3ºC

 Use of Clopirac


Clopirac is a potent and orally active inhibitor of prostaglandin synthetase. Clopirac is an anti-inflammatory agent[1].

 Names

Name 2-[1-(4-chlorophenyl)-2,5-dimethylpyrrol-3-yl]acetic acid
Synonym More Synonyms

 Clopirac Biological Activity

Description Clopirac is a potent and orally active inhibitor of prostaglandin synthetase. Clopirac is an anti-inflammatory agent[1].
Related Catalog
Target

prostaglandin synthetase[1]

References

[1]. Roba J, et al. Etude pharmacologique d'un nouvel anti-inflammatoire non stéroïdien, le clopirac [Pharmacological study of clopirac, a new anti-inflammatory agent (author's transl)]. J Belge Rhumatol Med Phys. 1975;30 Spec no:3-24.

 Chemical & Physical Properties

Density 1.23g/cm3
Boiling Point 429.1ºC at 760mmHg
Molecular Formula C14H14ClNO2
Molecular Weight 263.71900
Flash Point 213.3ºC
Exact Mass 263.07100
PSA 42.23000
LogP 3.37460

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9277490
CHEMICAL NAME :
1H-Pyrrole-3-acetic acid, 1-(4-chlorophenyl)-2,5-dimethyl-
CAS REGISTRY NUMBER :
42779-82-8
BEILSTEIN REFERENCE NO. :
0480479
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H14-Cl-N-O2
MOLECULAR WEIGHT :
263.74
WISWESSER LINE NOTATION :
T5NJ AR DG& B1 C1VQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
780 mg/kg
TOXIC EFFECTS :
Behavioral - analgesia Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 11,173,1976

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1-p-Chlorphenyl-2,5-dimethyl-pyrrol-3-essigsaeure
CP 172AP
EINECS 255-938-5
CLOPIRAC
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