Prostaglandin D2

Modify Date: 2025-08-23 11:40:19

Prostaglandin D2 structure	Common Name	Prostaglandin D2
	CAS Number	41598-07-6	Molecular Weight	352.465
	Density	1.1±0.1 g/cm3	Boiling Point	549.6±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₃₂O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	300.3±26.6 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Prostaglandin D2

Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

Name	prostaglandin D2
Synonym	More Synonyms

Description	Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
In Vivo	Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice[2]. Animal Model: Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)[1] Dosage: 5, 10, 20, or 50 pmol/min Administration: Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00 Result: Induced sleep-wake profiles.
References	[1]. Suzuki F, et al. Transport of prostaglandin D2 into brain. Brain Res. 1986 Oct 22;385(2):321-8. [2]. Zhang BJ, et al. Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice. Acta Pharmacol Sin. 2017 Apr;38(4):469-476. [3]. Kida T, et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS One. 2016 Dec 19;11(12):e0167729.

Density	1.1±0.1 g/cm3
Boiling Point	549.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.465
Flash Point	300.3±26.6 °C
Exact Mass	352.224976
PSA	94.83000
LogP	2.02
Vapour Pressure	0.0±3.4 mmHg at 25°C
Index of Refraction	1.561
Storage condition	20°C

Prostaglandin D2 MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK7930000

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9-alpha,13E,15S)-

CAS REGISTRY NUMBER :: 41598-07-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H32-O5

MOLECULAR WEIGHT :: 352.52

WISWESSER LINE NOTATION :: T5VTJ B1U7 C2U4VQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 400 ug/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 5 mg/L/24H

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 46,1688,1986

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	60-22
Safety Phrases	S22;S26;S36;S53
RIDADR	NONH for all modes of transport
RTECS	UK7930000

Precursor 4
CAS#:101249-10-9 (5Z,13E)-9α-[(t... CAS#:61305-35-9 (R)-(-)-BENZOIN CAS#:85800-97-1 methyl 7-oxohep... CAS#:72522-67-9 (1E)-iodo-(3S)-...
DownStream 1
CAS#:62410-84-8 9ALPHA, 11ALPHA...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Malva sylvestris L. extract suppresses desferrioxamine-induced PGE₂ and PGD₂ release in differentiated U937 cells: the development and validation of an LC-MS/MS method for prostaglandin quantification.

Biomed. Chromatogr. 28(7) , 986-93, (2014)

Malva sylvestris is a species used worldwide as an alternative to anti-inflammatory therapies; however, its mechanism of action remains unknown. In this paper, the anti-inflammatory effects of M. sylv...

PGD2

(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid

Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)-

Prostaglandin D2

(5Z,9α,13E,15S)-9,15-dihydroxy-11-oxo-prosta-5,13-dien-1-oic acid

MFCD00077857

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ProstaglandinD2
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Prostaglandin D2
Price: $1500.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Prostaglandin D2
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Get all suppliers and price by the below link:

Prostaglandin D2 suppliers

Prostaglandin D2 price

Prostaglandin D2

Use of Prostaglandin D2

Names