Piprofurol

Modify Date: 2024-01-04 14:42:59

Piprofurol structure	Common Name	Piprofurol
	CAS Number	40680-87-3	Molecular Weight	455.54300
	Density	1.214g/cm3	Boiling Point	640.7ºC at 760 mmHg
	Molecular Formula	C₂₆H₃₃NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	341.3ºC

Use of Piprofurol

Piprofurol is a calcium channel inhibitor. Piprofurol inhibites in a concentration-dependent manner the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].

Name	4-[3-[4,7-dimethoxy-6-(2-piperidin-1-ylethoxy)-1-benzofuran-5-yl]-3-hydroxypropyl]phenol
Synonym	More Synonyms

Description	Piprofurol is a calcium channel inhibitor. Piprofurol inhibites in a concentration-dependent manner the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	5 μM(guinea-pig papillary muscle)[1]
References	[1]. Pourrias B, et al. Calcium blocking properties of piprofurol. Arch Int Pharmacodyn Ther. 1985;274(2):223-239.

Density	1.214g/cm3
Boiling Point	640.7ºC at 760 mmHg
Molecular Formula	C₂₆H₃₃NO₆
Molecular Weight	455.54300
Flash Point	341.3ºC
Exact Mass	455.23100
PSA	84.53000
LogP	4.62440
Index of Refraction	1.596

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF6845120

CHEMICAL NAME :: 5-Benzofuranmethanol, 4,7-dimethoxy-alpha-(2-(4-hydroxyphenyl)ethyl)-6- (2-(1-piperidinyl)ethoxy)-

CAS REGISTRY NUMBER :: 40680-87-3

BEILSTEIN REFERENCE NO. :: 1276232

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C26-H33-N-O6

MOLECULAR WEIGHT :: 455.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 8,125,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,85,1974

EINECS 255-035-6

Piprofurol

Piprofurol [INN]

Piprofurolum

Piprofurolum [INN-Latin]

1-[4,7-dimethoxy-6-(2-piperidin-1-yl-ethoxy)-benzofuran-5-yl]-3-(4-hydroxy-phenyl)-propan-1-ol

Piprofurol

Use of Piprofurol

Names

Piprofurol Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms