Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)

Modify Date: 2025-08-22 14:03:04

Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1) Structure
Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1) structure
 Common Name Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)
CAS Number 3724-89-8 Molecular Weight 179.11000
Density 1.597g/cm3 Boiling Point 384.2ºC at 760mmHg
Molecular Formula C2H7NNaO3PS Melting Point 220ºC (dec.)(lit.)
MSDS Chinese USA Flash Point 186.2ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)


Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant[1][2].

 Names

Name sodium,2-aminoethylsulfanyl(hydroxy)phosphinate
Synonym More Synonyms

  Biological Activity

Description Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant[1][2].
Related Catalog
References

[1]. Gainer AL, et al. Cysteamine S-phosphate hydrolysis by pure human alkaline phosphatases and by sera from patients with lymphoproliferative disorders. Cancer Res. 1982 Sep;42(9):3507-9.

[2]. Besouw M, et al. Cysteamine: an old drug with new potential. Drug Discov Today. 2013 Aug;18(15-16):785-92.

 Chemical & Physical Properties

Density 1.597g/cm3
Boiling Point 384.2ºC at 760mmHg
Melting Point 220ºC (dec.)(lit.)
Molecular Formula C2H7NNaO3PS
Molecular Weight 179.11000
Flash Point 186.2ºC
Exact Mass 178.97800
PSA 121.49000
LogP 0.90950
InChIKey VZEGNYNPDZDIRW-UHFFFAOYSA-M
SMILES NCCSP(=O)([O-])O.[Na+]

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TE6483500
CHEMICAL NAME :
Phosphorothioic acid, S-(2-aminoethyl) ester, monosodium salt
CAS REGISTRY NUMBER :
3724-89-8
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C2-H7-N-O3-P-S.Na
MOLECULAR WEIGHT :
179.12
WISWESSER LINE NOTATION :
Z2SPQO&O &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
555 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
505 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1433 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
806 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1003 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
358 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
REFERENCE :
RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases 22-36/37/38
Safety Phrases S26;S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TE6483500

 Articles26

More Articles
A comparison of the effectiveness of cysteamine and phosphocysteamine in elevating plasma cysteamine concentration and decreasing leukocyte free cystine in nephropathic cystinosis.

Pediatr. Res. 23(6) , 616-20, (1988)

Cysteamine (beta-mercaptoethylamine, MEA) is currently used to treat children with nephropathic cystinosis. In this study MEA was compared to phosphocysteamine (MEAP), a phosphorothioester that tastes...

The treatment of cystinosis with cysteamine and phosphocysteamine in the United Kingdom and Eire.

Pediatr. Nephrol. 9(6) , 685-9, (1995)

Fifty-nine patients with cystinosis were treated with cysteamine or phosphocysteamine in the United Kingdom up to May 1990. Treatment was started at a median age of 3.2 years (range 0.6-24.8 years) an...

Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis.

J. Inherit. Metab. Dis. 35(5) , 847-57, (2012)

Infantile neuronal ceroid lipofuscinosis (INCL) is a profoundly neurodegenerative disease of children caused by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1). There is c...

 Synonyms

Phosphocysteamine
Tsistafos
MFCD00038474
Cystaphos sodium salt
Tsistafos (cystafos)
Cystaphos
Cistaphos
S-(2-Aminoethyl) thiophosphate monosodium salt
EINECS 223-079-5
Cystafos
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Chemsrc provides CAS#:3724-89-8 MSDS, density, melting point, boiling point, structure, etc. Its name is Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)>> amp version: Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)

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