AGN 195183
Modify Date: 2025-08-24 11:06:33
AGN 195183 structure
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Common Name | AGN 195183 | ||
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| CAS Number | 367273-07-2 | Molecular Weight | 437.864 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 500.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H22ClF2NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 256.7±30.1 °C | |
Use of AGN 195183AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.)Target: RARα agonistCompound 4(AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation.Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, compound 4 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients. |
| Name | AGN 195183 |
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| Synonym | More Synonyms |
| Description | AGN 195183 is a potent and selective agonist of RARα(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RARβ/γ.IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.)Target: RARα agonistCompound 4(AGN-195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation.Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T-47D and SK-BR-3, compound 4 does not cause the topical irritation induced by the RARa-selective retinoid, Am-580. Compound 4 (AGN 195183) is currently in Phase I/IIA clinical trials in cancer patients. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 500.9±50.0 °C at 760 mmHg |
| Molecular Formula | C22H22ClF2NO4 |
| Molecular Weight | 437.864 |
| Flash Point | 256.7±30.1 °C |
| Exact Mass | 437.120544 |
| LogP | 9.02 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.596 |
| Storage condition | 2-8℃ |
| 4-{[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)carbonyl]amino}-2,6-difluorobenzoic acid |
| RC87L028HU |
| 4-{[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}-2,6-difluorobenzoic acid |
| IRX-5183 |
| Benzoic acid, 4-[[(4-chloro-5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-2,6-difluoro- |