| Description |
T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM[1].
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| Related Catalog |
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| In Vitro |
T-705 can be converted to T-705RMP and T-705RTP by cellular kinases; Host cell enzymes can differentiate T-705, T-705RMP, and T-705RTP from the natural nucleotides. The level of inhibition of IMPDH by T-705RMP is about 150-fold weaker than that by Ribavirin monophosphate, and it became apparent that the antiviral effect of T-705 is not a result of the inhibition of the cellular enzyme[1].
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| References |
[1]. Furuta Y, et al. Mechanism of action of T-705 against influenza virus. Antimicrob Agents Chemother. 2005;49(3):981‐986.
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