GSK137647A
Modify Date: 2024-01-03 11:25:26
GSK137647A structure
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Common Name | GSK137647A | ||
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| CAS Number | 349085-82-1 | Molecular Weight | 305.39200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H19NO3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of GSK137647AGSK137647A is a selective FFA4 agonist, with pEC50 of 6.3, 6.2, and 6.1 for human, Mouse and Rat FFA4, respectively.IC50 value: 6.3/6.2/6.1 (pEC50, for human/mouse/rat FFA4)Target: FFA4The pEC50s for Human , Mouse and Rat FFA1/2/3 are ＜ 4.5. GSK137647A is evaluated against a panel of 65 targets in both full curve functional and binding assays and was shown to provide at least 100-fold selectivity against the panel which included 41 G-protein-coupled receptors (GPCRs), including additional members of the free fatty acid receptors (FFA1, FFA2, and FFA3). GSK137647A produces a concentration-dependent increase in glucose stimulated insulin secretion under high glucose conditions (25 mM). |
| Name | 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide |
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| Synonym | More Synonyms |
| Description | GSK137647A is a selective FFA4 agonist, with pEC50 of 6.3, 6.2, and 6.1 for human, Mouse and Rat FFA4, respectively.IC50 value: 6.3/6.2/6.1 (pEC50, for human/mouse/rat FFA4)Target: FFA4The pEC50s for Human , Mouse and Rat FFA1/2/3 are ＜ 4.5. GSK137647A is evaluated against a panel of 65 targets in both full curve functional and binding assays and was shown to provide at least 100-fold selectivity against the panel which included 41 G-protein-coupled receptors (GPCRs), including additional members of the free fatty acid receptors (FFA1, FFA2, and FFA3). GSK137647A produces a concentration-dependent increase in glucose stimulated insulin secretion under high glucose conditions (25 mM). |
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| Related Catalog | |
| References |
| Molecular Formula | C16H19NO3S |
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| Molecular Weight | 305.39200 |
| Exact Mass | 305.10900 |
| PSA | 63.78000 |
| LogP | 4.57500 |
| Appearance of Characters | white solid |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
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| gsk 137647 |
| GSK137647A |