GTP 14564

Modify Date: 2025-08-25 07:32:46

GTP 14564 Structure
GTP 14564 structure
 Common Name GTP 14564
CAS Number 34823-86-4 Molecular Weight 234.25
Density 1.321g/cm3 Boiling Point 459.1ºC at 760mmHg
Molecular Formula C15H10N2O Melting Point N/A
MSDS N/A Flash Point 240.7ºC

 Use of GTP 14564


GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and FLT3. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells[1].

 Names

Name 3-phenyl-1H-[1]benzofuro[3,2-c]pyrazole
Synonym More Synonyms

 GTP 14564 Biological Activity

Description GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and FLT3. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells[1].
Related Catalog
References

[1]. Murata K, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8.  

 Chemical & Physical Properties

Density 1.321g/cm3
Boiling Point 459.1ºC at 760mmHg
Molecular Formula C15H10N2O
Molecular Weight 234.25
Flash Point 240.7ºC
Exact Mass 234.07900
PSA 41.82000
LogP 3.97610
Index of Refraction 1.738
InChIKey DZQLVVLATXPWBK-UHFFFAOYSA-N
SMILES c1ccc(-c2n[nH]c3c2oc2ccccc23)cc1

 Safety Information

HS Code 2934999090

 Synthetic Route

3-chloro-1H-benzofuro[3,2-c]pyrazole structure

3-chloro-1H-ben...

CAS#:1094462-18-6

Phenylboronic acid structure

Phenylboronic acid

CAS#:98-80-6

~86%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Sales, Zachary S.; Mani, Neelakandha S. Journal of Organic Chemistry, 2009 , vol. 74, # 2 p. 891 - 894
3-phenyl-8b-p-toluenesulfonylamido-3a,8b-dihydro-1H-benzofuro(3,2-c)pyrazole structure

3-phenyl-8b-p-t...

CAS#:94511-17-8

~98%

Benzenesulfonamide structure

Benzenesulfonamide

CAS#:98-10-2

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-benzoyl-3-p-toluenesulfonylamidobenzofuran structure

2-benzoyl-3-p-t...

CAS#:94511-13-4

~11%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

N/A structure

N/A

CAS#:19726-12-6

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-benzoylbenzofuran-3-one structure

2-benzoylbenzof...

CAS#:5067-18-5

~92%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Zhou, Zhong-Zhen; Zou, Min; Zhou, Jia; Zhou, Chun-Qiong; Deng, Yan-Hong; Chen, Ming-Hui; Gu, Chun-Ping; Jiang, Zhi-Hong; Chen, Wen-Hua; Liu, Shu-Wen Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 1057 - 1061
3-BROMO-4-CHLOROTOLUENE structure

3-BROMO-4-CHLOR...

CAS#:49615-93-2

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-benzoyl-3-p-toluenesulfonylamidobenzofuran structure

2-benzoyl-3-p-t...

CAS#:94511-13-4

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
N/A structure

N/A

CAS#:94511-15-6

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-Benzoyl-3(2H)-benzofuranone structure

2-Benzoyl-3(2H)...

CAS#:2030-45-7

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Mosher,W.A. et al. Journal of Organic Chemistry, 1972 , vol. 37, p. 2402 - 2405
2-benzoyl-3-p-toluenesulfonylamidobenzofuran structure

2-benzoyl-3-p-t...

CAS#:94511-13-4

~%

Benzenesulfonamide structure

Benzenesulfonamide

CAS#:98-10-2

3-phenyl-8b-p-toluenesulfonylamido-3a,8b-dihydro-1H-benzofuro(3,2-c)pyrazole structure

3-phenyl-8b-p-t...

CAS#:94511-17-8

N/A structure

N/A

CAS#:94511-15-6

Detail
Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3-Phenyl-1H-benzofuro<3,2-c>pyrazol
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