Amelubant
Modify Date: 2024-01-17 16:13:28
Amelubant structure
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Common Name | Amelubant | ||
|---|---|---|---|---|
| CAS Number | 346735-24-8 | Molecular Weight | 568.70200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H40N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AmelubantAmelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. |
| Name | ethane,ethyl (NE)-N-[[4-[[3-[[4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy]methyl]phenyl]methoxy]anilino]methylidene]carbamate |
|---|---|
| Synonym | More Synonyms |
| Description | Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. |
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| Related Catalog | |
| Target |
LTB4:221 nM (Ki) LTB4:230 nM (Ki) |
| In Vitro | Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB4 receptor antagonists, with Kis of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively[1]. |
| References |
| Molecular Formula | C35H40N2O5 |
|---|---|
| Molecular Weight | 568.70200 |
| Exact Mass | 568.29400 |
| PSA | 92.87000 |
| LogP | 8.51260 |
| Ethyl ((4-((3-((4-(1-(4-hydroxyphenyl)-1-methylethyl)phenoxy)methyl)benzyl)oxy)phenyl)(imino)methyl)carbamate |
| Amelubant |
| UNII-E0018IF0K4 |
| Carbamic acid,((4-((3-((4-(1-(4-hydroxyphenyl)-1-methylethyl)phenoxy)methyl)phenyl)methoxy)phenyl)iminomethyl)-,ethyl ester |
| BIIL 284 |
| BIIL 283 BS |
| Amelubant [INN] |