MM 11253
Modify Date: 2024-01-06 12:16:36
MM 11253 structure
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Common Name | MM 11253 | ||
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| CAS Number | 345952-44-5 | Molecular Weight | 462.66700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H30O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MM 11253MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3]. |
| Name | 6-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid |
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| Description | MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3]. |
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| Related Catalog | |
| Target |
RARγ:44 nM (IC50) RARα:1000 nM (IC50) RARβ:>1000 nM (IC50) RXRα:>1000 nM (IC50) |
| In Vitro | MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth[2]. |
| References |
| Molecular Formula | C28H30O2S2 |
|---|---|
| Molecular Weight | 462.66700 |
| Exact Mass | 462.16900 |
| PSA | 87.90000 |
| LogP | 7.56810 |