L48H37
Modify Date: 2025-11-07 21:02:48
L48H37 structure
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Common Name | L48H37 | ||
|---|---|---|---|---|
| CAS Number | 343307-76-6 | Molecular Weight | 483.55300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H33NO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of L48H37L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages. L48H37 is used for the research of sepsis or lung injury treatment[1]. |
| Name | 1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one |
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| Description | L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages. L48H37 is used for the research of sepsis or lung injury treatment[1]. |
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| Related Catalog | |
| Target |
TLR4 |
| References |
| Molecular Formula | C27H33NO7 |
|---|---|
| Molecular Weight | 483.55300 |
| Exact Mass | 483.22600 |
| PSA | 75.69000 |
| LogP | 4.04770 |
| InChIKey | IOFNKUXFKVPLPF-KFSYKRRRSA-N |
| SMILES | CCN1CC(=Cc2cc(OC)c(OC)c(OC)c2)C(=O)C(=Cc2cc(OC)c(OC)c(OC)c2)C1 |
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L48H37 CAS#:343307-76-6 |
| Literature: Al-Omary, Fatmah A.M.; Hassan, Ghada S.; El-Messery, Shahenda M.; El-Subbagh, Hussein I. European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 65 - 72 |
| Precursor 2 | |
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| DownStream 0 | |