Phosphonoformic acid trisodium salt hexahydrate
Modify Date: 2025-08-25 05:58:37
Phosphonoformic acid trisodium salt hexahydrate structure
|
Common Name | Phosphonoformic acid trisodium salt hexahydrate | ||
|---|---|---|---|---|
| CAS Number | 34156-56-4 | Molecular Weight | 300.042 | |
| Density | N/A | Boiling Point | 490.7ºC | |
| Molecular Formula | CH12Na3O11P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 250.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Phosphonoformic acid trisodium salt hexahydrateFoscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3]. |
| Name | trisodium phosphonoformate hexahydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Phosphonoformic acid inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1]. Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2]. |
| Boiling Point | 490.7ºC |
|---|---|
| Molecular Formula | CH12Na3O11P |
| Molecular Weight | 300.042 |
| Flash Point | 250.6ºC |
| Exact Mass | 299.981018 |
| PSA | 168.51000 |
| InChIKey | ILRVASBWNRYBFD-UHFFFAOYSA-K |
| SMILES | O.O.O.O.O.O.O=C([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+] |
| Water Solubility | H2O: 0.1 g/mL hot, clear, colorless |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | SY8300000 |
|
Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility.
J. Virol. 89(8) , 4636-44, (2015) DNA polymerases of the Herpesviridae and bacteriophage RB69 belong to the α-like DNA polymerase family. In spite of similarities in structure and function, the RB69 enzyme is relatively resistant to f... |
| Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt, hydrate (1:3:6) |
| Foscarnet Sodium |
| Foscarnet sodium hexahydrate |
| Phosphonoformic acid trisodium salt hexahydrate |
| Sodium dioxidophosphinecarboxylate oxide hydrate (3:1:6) |
| Sodium phosphonatoformate hexahydrate |
| MFCD00150176 |
| phosphonoformicacidtrisodiumsalthexahydrate |